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Beilstein J. Org. Chem. 2018, 14, 2771–2778, doi:10.3762/bjoc.14.254
Graphical Abstract
Figure 1: Drugs and agrochemicals having a nicotinic acid derivative.
Scheme 1: One-pot access to (2-hydroxyaryl)pyridines.
Scheme 2: A possible mechanism for this sequential reaction.
Scheme 3: Substrate scope for (2-hydroxyaryl)nicotinates syntheses. The reaction was performed with 1a–e (0.2...
Scheme 4: One-pot synthesis of (2-hydroxyaryl)nicotinonitriles 5ak–5am.